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                         The Ultimate Guide To Capecitabine

 

Capecitabine

Capecitabine medication can interact with Several other medicines and herbal merchandise. Notify your medical doctor or pharmacist about any medicines you are using. This incorporates nutritional vitamins, herbal supplements and over the counter solutions.

Mouth sores and ulcers is often unpleasant. It helps to keep the mouth and tooth clear, consume a lot of fluids, steer clear of acidic foods which include oranges, lemons and grapefruits, and chew gum to maintain the mouth moist. Notify your health practitioner or nurse For those who have ulcers.

Tummy (abdominal) discomfort and discomfort in other parts of the human body You may perhaps get tummy discomfort or considerably less normally you will have suffering in other aspects of Your whole body which include your joints, arms, legs and back.

Chemotherapy is often given like a system of several cycles of therapy over several months. The procedure cycle could past 21, 28 or 35 times. This is dependent upon your unique treatment method approach. Your nurse or medical doctor will examine your cure approach with you. The nurse or pharmacist will provide you with the tablets to take home. You might also get a copy on the procedure approach so you recognize when to acquire your prescription drugs. Normally get them just as spelled out. This is crucial to be certain they operate as well as you possibly can in your case.

Capecitabine is employed alone as an adjuvant therapy next the complete resection of Key tumor in clients with stage III colon cancer when monotherapy with fluroprymidine is preferred. The use or capecitabin together regimens for Superior gastric cancer is now getting investigated.

Your medical professional can provide you with prescription drugs that will help Regulate some Negative effects. It is necessary to consider them specifically as your nurse or pharmacist points out.

Sensation or getting sick is usually well managed with anti sickness medicines. Averting fatty or fried foods, feeding on tiny meals and snacks, drinking loads of h2o, and rest methods can all help.

Acetaminophen could reduce the excretion amount of Capecitabin which could end in an increased serum amount.

In case you have DPD deficiency, This will impact the solutions that are available for you. You won’t know with no exam When you have DPD deficiency, as there isn’t any signs and symptoms. Testing can detect most conditions of DPD deficiency, but not all scenarios. You are able to discuss with your most cancers medical doctor regarding your danger of having DPD deficiency Before you begin cure.

We are not able to listing each individual facet effect for this treatment method. There are several exceptional Unwanted side effects that are not stated. You can go to the electronic Medicines Compendium (eMC) for more detailed information and facts.

You could get agony with your joints or other locations, for instance your back, all through treatment method. If this happens, notify your medical professional so that they can present you with painkillers. Tell them If your discomfort does not get well. Having warm baths and using normal rests may well assistance.

Indications are discomfort, redness and swelling exactly where the clot is. Feeling breathless might be a indicator of a blood clot during the lung. Get hold of your tips line or medical professional straight away When you have any of such signs or symptoms

Get hold of your information line if you have diarrhoea, for example if you’ve had 4 or maybe more free watery poos (stools) in 24 several hours. Or if You can not consume to replace the lost fluid. Or if it carries on for more than 3 days.

 

Capecitabine

(ka pe SITE a been)

Brand Name: Xeloda®

Capecita is the generic name for the trade name drug Xeloda. In some cases, health care professionals may use the trade name Xeloda when referring to the generic drug name capecitabin.

Drug Type:

Capecitabin is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. Capecitabine is classified as an “antimetabolite.” (For more detail, see “How Works” section below).

What Is Used For:

Colon or rectal cancer

Metastatic breast cancer

Esophageal, gastric, hepatobiliary, neuroendocrine, pancreatic, ovarian, fallopian tube, peritoneal or unknown primary cancers (off-label use)

Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.

How Capecitabine Is Given:

Taken as a pill by mouth.

Take after food (within 30 minutes of a meal) with water. (Usually taken in a divided dose 12 hours apart).

Tablets come in 2 sizes; 150mg and 500mg.

Do not crush, chew or dissolve tablets.

If you miss a dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses.

The amount of that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated. Your doctor will determine your dose and schedule.

Side Effects:

Important things to remember about the side effects of capecitabine:

Most people will not experience all of the side effects listed.

Capecitabin side effects are often predictable in terms of their onset, duration, and severity.

Capecitabin side effects will improve after therapy is complete.

Capecitabin side effects may be quite manageable. There are many options to minimize or prevent the side effects of capecitabine.

The following side effects are common (occurring in greater than 30%) for patients taking capecitabine:

Low white blood cell count (This can put you at increased risk for infection)

Low red blood cell count (anemia)

Nadir: Meaning low point, nadir is the point in time between chemotherapy cycles in which you experience low blood counts.

Onset: N/A

Nadir: 10-14 days

Recovery: N/A

Hand-foot syndrome (Palmar-plantar erythrodysesthesia or PPE) – skin rash, swelling, redness, pain and/or peeling of the skin on the palms of hands and soles of feet. Usually mild, has started as early as 2 weeks after start of treatment. May require reductions in the dose of the medication)

Diarrhea

Elevated liver enzymes (increased bilirubin levels) (see liver problems)

Fatigue

Nausea and vomiting

Rash & itching

Abdominal pain

These side effects are less common side effects (occurring in about 10-29%) of patients receiving.

Poor appetite

Low platelet count (This can put you at increased risk for bleeding)

Mouth sores

Fever

Swelling of the feet and ankles

Eye irritation

Constipation

Back, muscle, joint, bone pain (see pain)

Headache

GI Motility disorder

Numbness or tingling (hands or feet)

Not all side effects are listed above. Some that are rare (occurring in less than 10% of patients) are not listed here. However, you should always inform your health care provider if you experience any unusual symptoms.

When To Contact Your Doctor or Health Care Provider:

Contact your health care provider immediately, day or night, if you should experience any of the following symptoms:

Fever of 100.4° F (38° C) or higher, chills (possible signs of infection)

The following symptoms require medical attention, but are not an emergency. Contact your health care provider within 24 hours of noticing any of the following:

Nausea (interferes with ability to eat and unrelieved with prescribed medication).

Vomiting (vomiting more than 4-5 times in a 24 hour period)

Diarrhea (4-6 episodes in a 24-hour period)

Unusual bleeding or bruising

Black or tarry stools, or blood in your stools or urine

Constipation

Extreme fatigue (unable to carry on self-care activities)

Mouth sores (painful redness, swelling or ulcers)

Swelling, redness and/or pain in one leg or arm and not the other

Yellowing of the skin or eyes

Tingling or burning, redness, swelling of the palms of the hands or soles of the feet.

Confusion, loss of balance, excessive sleepiness

Always inform your health care provider if you experience any unusual symptoms.

Precautions:

Before starting capecitabin treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, products containing aspirin unless your doctor specifically permits this.

Avoid use of antacids within 2 hours of taking.

If you are on warfarin (Coumadin®) as a blood-thinner, adjustments may need to be made to your dose based on blood work.

Capecitabin may be inadvisable if you have had a hypersensitivity (allergic) reaction to fluorouracil.

Do not receive any kind of immunization or vaccination without your doctor’s approval while taking.

Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category D (capecitabin may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus).

For both men and women: Do not conceive a child (get pregnant) while taking capecitabin. Barrier methods of contraception, such as condoms, are recommended. Discuss with your doctor when you may safely become pregnant or conceive a child after therapy.

Do not breast feed while taking capecitabine.

You might have capecitabine as a course of several cycles of treatment Open a glossary item. Each cycle is often over 3 weeks, but this depends on the type of cancer you have.

For example, you may take capecitabine every day for 2 weeks. Then have a week with no treatment. You then start the next cycle. Or you may take every day for a few months.

Your doctor will tell you:

what dose of you need to take

when to take it

how long to take it for

Tests

You have blood tests before and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.

Before starting treatment with capecitabine you have a blood test to check levels of an enzyme called dihydropyrimidine dehydrogenase (DPD).

A low DPD level might mean you are more likely to have severe side effects from these drugs. So you may start treatment with a lower amount (dose) of the drug or have a different treatment. Your doctor or nurse will talk to you about this.

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